I just went looking to support or disprove my hypothesis.
In mineral based oil, molecule size and shape determine viscosity. The larger the molecule, the higher the viscosity.
However, in synthetic oil, the molecule size doesn't change.
Would this suggest that synthetic oil mix ratios should have less affect on tuning?
So on one hand we're arguing semantics. On the other hand, I prefer to think of reduced flow due to larger molecules, rather than being "thicker".
Here's a quote from another source.
"A typical example: you go from a 50:1 ratio to a 20:1 ratio. Your engine will now run leaner, and you’ll have to make jetting changes. You’ll need bigger (in number) jets because the oil molecules are thicker and the flow rate (the amount coming through the jet) is less."