I don't have any direct experience with die-casting metal, but do with plastic, and I'm quite confident they share the same problems. Namely, when there is a relatively large mass of material, the piece must be kept in the closed die longer and with continued pressure on the injected material, or the larger mass will cool too quickly with attendant shrinking/cracking which may be merely unsightly at best. A bearing boss with internal cracks/voids will not be as strong as one which has less material overall but which is solid and has well-formed structure throughout.
Glen