The knot/dna/tangled molecule relationship isn't new; but nor is the theoretical mathematical knots of visual arts.
But, i think as a win for the common man, the definition by not form(thrown together/laced/unloaded), but rather function (loaded/ in action) is the answer. As working folk; in our own way are leaps ahead! It is better (IMLHO) to see things in view of purpose/ target value, rather than whatever it masquerades as/how it appears.
Sure, you have to know how to tie something; but dressing, setting, inspecting, loading, reading back info for next time etc.; knowing what k/not to use, where trouble is, what trustworthy knots are wrong in what materials, conditions etc. is the most important!
Many an overlooked lessons in the simplest Square Knot (family); that can cripple the rest of the understandings!