That all depends on your frequency of usage. I don't use them daily, they might sit for a month or more unused so the cost of the canned fuel for me is inconsequential and I don't have to buy 2 stroke oil either as it's already in the canned fuel, in my case Echo Red Armor.
I might use 3 gallons of synthetic gas in a full year, maybe.
Makes a dandy overwintering fuel for my gas powered lawn equipment as well. Of course my big mower is a diesel (Kubota F Series) so that isn't an issue.
Think I paid 10 bucks each for the last couple gallons I bought. Get it at cost from the dealer I work at.
I can see using weasel pee with 2 stroke oil added if you are in the business of using them daily, or even non E gas, but in my situation it's not germane.
Scary part for me would be exactly how much alcohol is actually added to the no lead gas before you purchase it. Read somewhere that refiners were upping the amount to over 10% and I read (but have no knowledge of it) that regular unleaded with an alcohol content of over 10% by volume is really hard on small engines, especially air cooled ones. Why, I have no idea actually.
I do know that running e-gas in your buggy, eliminates the need for dry gas in the winter, a plus up here in the frozen north.