I used to run 404 full comp on my 3120 Husky for the 50" bar, then stepped down to .375 when we put on the 36" bar. Too much work! We keep everything in .404, since the 3/8th chain breaks too often. All those claims of greater cutting speed don't count when you loose time on a broken chain.
I still have a lot of .404 full comp, and we are keeping that on the 36" bar, but I am slowly changing to skip tooth for the 50" bar. It's not that the full comp takes too much power...nope. Got lots of that. In a big cut, it takes too much force to keep cutting pressure on all the teeth. As the cut gets longer, the chips get smaller and the cut slows waaay down, especially if you are obliged to cut without the dogs on the top of the bar. So you jockey the saw around to keep the contact area smaller, and it is a lot of moving around to keep everything cutting well. Not always a practical way to cut, especially on a big stump next to a concrete foundation.
The skip tooth cuts better on a long sweep through the wood, especially on a big stump where the cutters get dulled quickly.