1 3/4 turns is a bit much. Is the tuning consistent at that or does it lose it over time, does the saw run held upside down, sideways etc.?
Can you describe how you perform the vac and pressure test? What I mean is do you have the saw as fully assembled as possible - piece of rubber behind the carb, impulse line connected but blocked with a golf tee? I have been tricked by doing a partial test of a 460, this way you are testing everything - intake boot, impulse line etc. Plug the decomp to take that out of the equation.
Try a shorter bar and chain and see if that helps? Try a new chain. 25' is quite long for this saw.
There could be something sticking in the carb, have you cleaned it totally?
Try removing the fuel filter (temporarily). This can highlight fuel flow problems. check fuel tank breather. what happens if you cut with the saw held sideways and the fuel cap off?