I have to agree with Jim. While I really like to play with odd ball calibers, like my 348 Winchester and 220 Swift, my current hunting rifle is a hot loaded 06, and I have taken the vast majority of my deer with a slightly down loaded 300 Win Mag. So, I guess I kinda gravitate to a 30 cal at about 300 H+H velocities.
That said, the 308 makes an excellent all around hunting cartridge.
For practical purposes, the 30 cal cartridges are just real hard to beat. They hit hard, are VG in heavy brush (with the right bullets, and I've had problems with 270 in brush), and shoot flat enough for open field shots.